Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 9/20 | 0.40 |
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PEPD | P12955 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789454 | 0.87 | ACE (0.47) | RAB9AACERENLMNAHSD17B10 | |
| SCHEMBL6789463 | 0.87 | ACE (0.47) | RAB9AACERENLMNAHSD17B10 | |
| SCHEMBL6789470 | 0.87 | ACE (0.47) | RAB9AACERENLMNAHSD17B10 | |
| SCHEMBL13825896 | 0.78 | ACE (0.47) | RAB9AACERENLMNAHSD17B10 | |
| SCHEMBL7296775 | 0.74 | ACE (0.50) | RAB9AACEALDH1A1SMN1; SMN2 | |
| SCHEMBL6206281 | 0.74 | CHRM2 (0.38) | RAB9A | |
| SCHEMBL7257281 | 0.74 | ACE (0.40) | RAB9AACERENLMNAHSD17B10 | |
| SCHEMBL7299201 | 0.73 | ACE (0.55) | RAB9AACERENACE2 | |
| SCHEMBL2444893 | 0.73 | ACE (0.55) | RAB9AACEREN | |
| SCHEMBL2177826 | 0.72 | ACE (0.51) | RAB9AACERENLMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915088-B1 | D-Proline derivatives | HOFFMANN LA ROCHE (CH) | 2002-09-18 | — | — | EP | claimed |