Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 6/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9584121 | 0.84 | MAPT (0.46) | MAPTALDH1A1GAAHSD17B10LMNA | |
| SCHEMBL7298125 | 0.76 | MAP3K14 (0.43) | MAPTNPC1RAB9A | |
| SCHEMBL7291256 | 0.76 | MAPT (0.50) | MAPTGAALMNAL3MBTL1NPC1 | |
| SCHEMBL7292136 | 0.76 | FABP6 (0.38) | MAPTALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL14626669 | 0.73 | MAPT (0.40) | MAPTALDH1A1GAAHSD17B10LMNA | |
| SCHEMBL3844432 | 0.72 | MAPT (0.35) | MAPTALDH1A1HSD17B10LMNANPC1 | |
| SCHEMBL11905 | 0.72 | MAPT (0.53) | MAPTALDH1A1GAAHSD17B10LMNA | |
| SCHEMBL131072 | 0.70 | ITGB2 (0.52) | MAPTGAALMNASMN1; SMN2KMT2A | |
| SCHEMBL3534932 | 0.68 | MAOB (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL29636337 | 0.68 | ALDH1A1 (0.50) | MAPTALDH1A1GAAHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260444-A | Cardiovascular, hypotensive | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5208245-A | Hypotensive agents | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0460418-A2 | Novel Dihydropyridine derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-12-11 | — | — | EP | disclosed |