Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | MC3R | P41968 | 1/20 | 0.41 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874457 | 0.81 | KDM4E (0.48) | IDO1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL30373798 | 0.79 | ADORA3 (0.50) | IDO1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15572404 | 0.79 | IDO1 (0.48) | IDO1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15571198 | 0.79 | KDM4E (0.47) | IDO1HDAC3HDAC1HDAC2HDAC6 | |
| Hydrochloric Acid SCHEMBL1373071 | 0.79 | KDM4E (0.47) | IDO1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15571571 | 0.79 | KDM4E (0.47) | IDO1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1483374 | 0.79 | ADORA3 (0.50) | IDO1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4086758 | 0.79 | IDO1 (0.44) | IDO1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15572500 | 0.79 | KDM4E (0.47) | IDO1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL28788425 | 0.79 | IDO1 (0.41) | IDO1HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407114-B1 | BENIGN PROSTATIC HYPERPLASIA, CARDIOVASCULAR, GASTROINTESTINAL AND RESPIRATORY DISORDER TREATMENT; ANTIASTHMATIC, ANTIALLERGEN, AND ANTIDIABETIC AGENTS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| EP-0995751-A2 | Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction | PFIZER INC. (US) | 2000-04-26 | — | — | EP | disclosed |