Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 5/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303524 | 0.88 | CA1 (0.38) | CES1CES2ALDH1A1DDAH1CNR1 | |
| SCHEMBL3385862 | 0.81 | CES1 (0.48) | CES1CES2ALDH1A1TP53CA1 | |
| SCHEMBL840804 | 0.81 | CES1 (0.48) | CES1CES2ALDH1A1TP53CA1 | |
| SCHEMBL7310476 | 0.79 | CES1 (0.42) | CES1CES2ALDH1A1TP53CA1 | |
| SCHEMBL7303621 | 0.79 | CES1 (0.46) | CES1CES2ALDH1A1TP53CA1 | |
| SCHEMBL7307380 | 0.79 | CA1 (0.36) | ALDH1A1CA1 | |
| SCHEMBL7307183 | 0.77 | CES2 (0.46) | CES1CES2ALDH1A1MEN1KMT2A | |
| SCHEMBL4674704 | 0.75 | CES1 (0.42) | CES1CES2ALDH1A1TP53DDAH1 | |
| SCHEMBL7694619 | 0.74 | CES2 (0.50) | CES1CES2ALDH1A1MEN1KMT2A | |
| SCHEMBL7308332 | 0.74 | CES2 (0.50) | CES1CES2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| EP-0502314-A1 | Benzimidazol, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-09-09 | — | — | EP | disclosed |