SCHEMBL7299338

SCHEMBL7299338

CC(C)(N)CNC(=O)[C@H](Cc1ccccc1)C[C@H](O)[C@H](CC1CCCCC1)N(C(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)[C@@H](Cc1c[nH]cn1)C(N)=O

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
REN P00797 19/20 0.46
PGC P20142 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7298725 0.92 REN (0.45) RENPGC
SCHEMBL7440050 0.89 REN (0.49) RENPGC
SCHEMBL9523860 0.88 REN (0.46) RENPGC
SCHEMBL7375184 0.84 REN (0.44) REN
SCHEMBL7314665 0.83 REN (0.46) RENPGC
SCHEMBL7309930 0.83 REN (0.46) RENPGC
SCHEMBL7319702 0.83 REN (0.43) RENPGC
SCHEMBL10767935 0.82 REN (0.44) REN
SCHEMBL7313163 0.80 REN (0.43) RENPGC
SCHEMBL7326765 0.80 REN (0.43) RENPGC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4985407-A Dipeptide compounds, processes for their preparation and compositions containing them GLAXO GROUP LIMITED (GB) 1991-01-15 US disclosed
EP-0320205-A2 Renin inhibiting dipeptides, their preparation and compositions containing them GLAXO GROUP LIMITED (GB) 1989-06-14 EP disclosed