Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP4B1 | P13584 | 2/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.47 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.47 |
| ▸ | CYP2A7 | P20853 | 2/20 | 0.47 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.47 |
| ▸ | CYP2F1 | P24903 | 2/20 | 0.47 |
| ▸ | CYP2C18 | P33260 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.47 |
| ▸ | CYP4F8 | P98187 | 2/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL730859 | 0.82 | CNR2 (0.46) | ACHEALDH1A1 | |
| SCHEMBL733034 | 0.81 | TSHR (0.43) | CYP1A1CYP1A2CYP1B1PDGFRBNOTUM | |
| SCHEMBL733133 | 0.81 | PDGFRB (0.47) | CYP1A1CYP1A2CYP1B1PDGFRBPDGFRA | |
| SCHEMBL5924635 | 0.79 | CYP3A4 (0.61) | CYP3A4CYP1A1CYP1A2CYP2E1CYP2C8 | |
| SCHEMBL733057 | 0.79 | CA1 (0.44) | GAACA1CA2CA7CA9 | |
| SCHEMBL733149 | 0.78 | CYP1A1 (0.56) | CYP3A4CYP1A1CYP1A2CYP2E1CYP2C8 | |
| SCHEMBL730765 | 0.77 | CA12 (0.46) | CLK4ACHECA1CA2CA7 | |
| SCHEMBL28618241 | 0.77 | AKR1C3 (0.48) | DYRK1AGAAALDH1A1 | |
| SCHEMBL29489425 | 0.76 | CYP3A4 (0.73) | CYP3A4CYP1A1CYP1A2CYP2E1CYP2C8 | |
| SCHEMBL196765 | 0.76 | CYP3A4 (0.73) | CYP3A4CYP1A1CYP1A2CYP2E1CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-B1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME (US) | 2013-08-14 | — | — | EP | disclosed |
| US-8138197-B2 | Spirochromanon derivatives | MSD K.K. (JP) | 2012-03-20 | — | — | US | disclosed |
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | MERCK SHARP & DOHME LLC | 2009-10-29 | — | — | US | disclosed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270436-A1 | SPIROCHROMANON DERIVATIVES | AKR1C3, CBR3, AKR1C4 | CYP3A4 410/4885CYP1A1 45/4885CYP1A2 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.