Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TLR3 | O15455 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 11/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16314481 | 0.81 | BACE1 (0.38) | P2RX7BACE1 | |
| SCHEMBL1693343 | 0.81 | CNR1 (0.40) | CNR1CNR2SMN1; SMN2P2RX7PTGDR2 | |
| SCHEMBL18524121 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2P2RX7PTGDR2BACE1 | |
| SCHEMBL7300199 | 0.74 | EPHX2 (0.42) | CNR1CNR2SMN1; SMN2TLR3P2RX7 | |
| SCHEMBL7301219 | 0.74 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL29875436 | 0.73 | IDO1 (0.36) | SMN1; SMN2P2RX7 | |
| SCHEMBL3580439 | 0.73 | MEN1 (0.43) | CNR1CNR2TLR3 | |
| SCHEMBL15021653 | 0.73 | MEN1 (0.43) | CNR1CNR2TLR3 | |
| SCHEMBL31253977 | 0.73 | MEN1 (0.43) | CNR1CNR2TLR3 | |
| SCHEMBL13573386 | 0.73 | MEN1 (0.43) | CNR1CNR2TLR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308792-B1 | AZACHROMANE DERIVATIVES | MERCK PATENT GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |
| US-4931454-A | Azachroman derivatives with effects on the cardiovascular system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-06-05 | — | — | US | disclosed |
| EP-0308792-A2 | Azachromane derivatives | MERCK PATENT GmbH (DE) | 1989-03-29 | — | — | EP | disclosed |