Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 16/20 | 0.67 |
| ▸ | MMP1 | P03956 | 13/20 | 0.55 |
| ▸ | ADAMTS4 | O75173 | 7/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP10 | P09238 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204557 | 0.90 | MMP13 (0.69) | MMP13MMP1ADAMTS4ADAM17MMP3 | |
| SCHEMBL7201008 | 0.89 | MMP13 (0.54) | MMP13MMP1ADAMTS4ADAM17MMP3 | |
| SCHEMBL7205953 | 0.89 | MMP13 (0.71) | MMP13MMP1ADAMTS4ADAM17MMP3 | |
| SCHEMBL7204063 | 0.88 | MMP13 (0.53) | MMP13MMP1ADAMTS4ADAM17MMP3 | |
| SCHEMBL7201536 | 0.88 | MMP13 (0.53) | MMP13MMP1ADAMTS4ADAM17MMP3 | |
| SCHEMBL7203099 | 0.88 | MMP13 (0.53) | MMP13MMP1ADAMTS4ADAM17MMP3 | |
| SCHEMBL7205449 | 0.88 | MMP13 (0.53) | MMP13MMP1ADAMTS4ADAM17MMP3 | |
| SCHEMBL7201237 | 0.87 | MMP13 (0.52) | MMP13MMP1ADAMTS4ADAM17MMP3 | |
| SCHEMBL7204209 | 0.86 | MMP13 (0.70) | MMP13MMP1ADAMTS4ADAM17 | |
| SCHEMBL7205270 | 0.85 | MMP13 (0.72) | MMP13MMP1ADAMTS4ADAM17MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1138680-A1 | Gem substituted sulfonyl hydroxamic acids as MMP inhibitors | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | disclosed |