Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796229 | 0.79 | MAPT (0.62) | ALDH1A1SMN1; SMN2HPGDLMNAMEN1 | |
| SCHEMBL11236178 | 0.78 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MAPK1HPGDLMNA | |
| SCHEMBL9444240 | 0.78 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPK1HPGDLMNA | |
| SCHEMBL10273174 | 0.78 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL15199253 | 0.78 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL5208082 | 0.78 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL20561121 | 0.76 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL20561118 | 0.76 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPK1LMNAHTT | |
| SCHEMBL1248863 | 0.76 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL7300899 | 0.75 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2MAPK1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |