Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.40 |
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11637547 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11657483 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL7298081 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11634656 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11634644 | 0.81 | PDE3A (0.47) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11737729 | 0.77 | PDE3A (0.48) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11702816 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL20705949 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11254453 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL7300917 | 0.74 | POLB (0.48) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| US-4082843-A | 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1978-04-04 | — | — | US | disclosed |