Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 7/20 | 0.61 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.58 |
| ▸ | ACE | P12821 | 2/20 | 0.57 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.56 |
| ▸ | ANPEP | P15144 | 1/20 | 0.56 |
| ▸ | IL1RN | P18510 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29435426 | 0.89 | ECE1 (0.77) | ECE1ERAP2ACEERAP1ANPEP | |
| SCHEMBL14940856 | 0.89 | ECE1 (0.77) | ECE1ERAP2ACEERAP1ANPEP | |
| SCHEMBL5369872 | 0.89 | ECE1 (0.77) | ECE1ERAP2ACEERAP1ANPEP | |
| SCHEMBL29531224 | 0.89 | ECE1 (0.77) | ECE1ERAP2ACEERAP1ANPEP | |
| SCHEMBL29448679 | 0.89 | ECE1 (0.77) | ECE1ERAP2ACEERAP1ANPEP | |
| SCHEMBL11589639 | 0.89 | ECE1 (0.77) | ECE1ERAP2ACEERAP1ANPEP | |
| SCHEMBL30051190 | 0.87 | ECE1 (0.74) | ECE1ERAP2ACEERAP1ANPEP | |
| SCHEMBL30052122 | 0.86 | ECE1 (0.69) | ECE1ERAP2ACEERAP1IL1RN | |
| SCHEMBL31564765 | 0.86 | ECE1 (0.69) | ECE1ERAP2ACEERAP1IL1RN | |
| SCHEMBL30051690 | 0.86 | ERAP2 (0.73) | ECE1ERAP2ACEERAP1ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691985-B1 | PHOSPHONOMETHYLDIPEPTIDES | MERRELL PHARMA INC (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5608078-A | Phosphonomethyldipeptides and process for preparation thereof | MERRELL PHARMACEUTICALS INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0691985-A1 | PHOSPHONOMETHYLDIPEPTIDES | MERRELL PHARMACEUTICALS INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022908-A1 | PHOSPHONOMETHYLDIPEPTIDES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-10-13 | — | — | WO | disclosed |
| EP-0618224-A1 | Phosphonomethyldipeptides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-10-05 | — | — | EP | disclosed |