Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.68 |
| ▸ | PDE4A | P27815 | 5/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.68 |
| ▸ | SNCA | P37840 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA3 | P07451 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301103 | 1.00 | KDM4E (0.69) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL30025682 | 1.00 | KDM4E (0.69) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL28496638 | 0.95 | KDM4E (0.69) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL20809899 | 0.92 | KDM4E (0.69) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL7324806 | 0.90 | PDE4B (0.60) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL7324802 | 0.90 | PDE4B (0.60) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL7357136 | 0.90 | PDE4B (0.68) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL7332000 | 0.90 | PDE4B (0.68) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL7331992 | 0.90 | PDE4B (0.68) | KDM4EALDH1A1HPGDALOX15MAPK1 | |
| SCHEMBL7929068 | 0.90 | PDE4B (0.68) | KDM4EALDH1A1HPGDALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | claimed |
| CN-112209848-A | Cyclopentane-containing cinnamamide derivative with neuroprotective activity and preparation method thereof | 中山大学 | 2021-01-12 | — | — | CN | disclosed |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2018-07-10 | — | — | US | disclosed |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2018-07-10 | — | — | US | disclosed |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | UNIVERSITA DEGLI STUDI DI GENOVA (IT) | 2018-07-10 | — | — | US | disclosed |
| EP-3105206-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | Universita' degli Studi di Genova (IT) | 2016-12-21 | — | — | EP | disclosed |
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY | 2016-12-08 | — | — | US | disclosed |
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY | 2016-12-08 | — | — | US | disclosed |
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY | 2016-12-08 | — | — | US | disclosed |
| WO-2015121212-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | UNIVERSITÀ DEGLI STUDI DI GENOVA (IT) | 2015-08-20 | — | — | WO | disclosed |
| EP-0511865-B1 | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents | AMERICAN HOME PROD (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1994027947-A1 | PHENYLCYCLOPROPANE COMPOUNDS AND THEIR USE AS cAMP AND TNF INHIBITORS | RHONE-POULENC RORER LTD. (GB) | 1994-12-08 | — | — | WO | disclosed |
| EP-0626939-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994014742-A1 | TRI-SUBSTITUTED PHENYL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | CELLTECH LIMITED (GB) | 1994-07-07 | — | — | WO | disclosed |
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| US-5250700-A | Phosphodiesterase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |
| WO-1993015045-A1 | N-(3-PHENYLPROPYL)OXAMIC ACID, OXAMATE, AND OXAMIDE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-08-05 | — | — | WO | disclosed |
| US-5191084-A | PHENYL PYRAZOLIDINONES AS BRONCHODILATORS AND ANTI-INFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-02 | — | — | US | disclosed |
| EP-0511865-A1 | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-11-04 | — | — | EP | disclosed |
| US-4971959-A | Trisubstituted phenyl analogs having activity for congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1990-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355489-A1 | NEW COMPOUNDS HAVING A SELECTIVE PDE4D INHIBITING ACTIVITY | PDE4A, PDE4D, PDE4B | KDM4E 553/4885ALDH1A1 591/4885HPGD 2279/4885 |
| US-10017480-B2 | Compounds having a selective PDE4D inhibiting activity | PDE4A, PDE4D, PDE2A | KDM4E 448/4885ALDH1A1 599/4885HPGD 1924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.