Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.68 |
| ▸ | PDE4A | P27815 | 3/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.68 |
| ▸ | APP | P05067 | 3/20 | 0.58 |
| ▸ | FDPS | P14324 | 1/20 | 0.58 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7929062 | 1.00 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CAPP | |
| SCHEMBL15827634 | 0.94 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CAPP | |
| SCHEMBL7331992 | 0.90 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL30025682 | 0.90 | KDM4E (0.69) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7325725 | 0.90 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7357136 | 0.90 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7301103 | 0.90 | KDM4E (0.69) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7301099 | 0.90 | KDM4E (0.69) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7332000 | 0.90 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4CNFE2L2 | |
| SCHEMBL7326891 | 0.88 | PDE4B (0.67) | PDE4BPDE4DPDE4APDE4CFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248769-B1 | ANTIINFLAMMATORY AGENT | EURO-CELTIQUE S.A. (LU) | 2001-06-19 | — | — | US | disclosed |
| US-6103749-A | PHENYL IMIDAZOLE COMPOUNDS USEFUL FOR TREATMENT OF ASTHMA, ALLERGIES, INFLAMMATION AND DEPRESSION | EURO-CELTIQUE S.A. (LU) | 2000-08-15 | — | — | US | disclosed |
| EP-0720600-B1 | 3-(3,4-DIOXYPHENYL)-PYRROLIDINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ICOS CORP (US) | 2000-07-12 | — | — | EP | disclosed |
| WO-2000001387-A1 | FUNGAL GROWTH INHIBITORS | CELGRO, A DIVISION OF CELGENE CORPORATION (US) | 2000-01-13 | — | — | WO | disclosed |
| US-5922751-A | BRONCHODILATOR AND ANTIINFLAMMATORY AGENT WITHOUT UNDESIRABLE CARDIOVASCULAR STIMULATION CAUSED BY PHOSPHODIESTERASE III INHIBITOR | EURO-CELTIQUE, S.A. (LU) | 1999-07-13 | — | — | US | disclosed |
| US-5665754-A | Substituted pyrrolidines | GLAXO WELLCOME INC. (US) | 1997-09-09 | — | — | US | disclosed |