Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.59 |
| ▸ | PDE4A | P27815 | 12/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | VEGFA | P15692 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PDE1A | P54750 | 1/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295171 | 0.89 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7294335 | 0.89 | PDE4A (0.53) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5964136 | 0.89 | PDE4A (0.58) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7292161 | 0.89 | PDE4A (0.58) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7294704 | 0.89 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| Hydrochloric Acid SCHEMBL7296576 | 0.88 | PDE4A (0.52) | PDE4BPDE4APDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7302284 | 0.88 | PDE4A (0.52) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| Hydrochloric Acid SCHEMBL7290286 | 0.88 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL7290554 | 0.88 | PDE4B (0.62) | PDE4BPDE4APDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7293355 | 0.87 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511865-B1 | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents | AMERICAN HOME PROD (US) | 1997-01-29 | — | — | EP | claimed |
| US-5250700-A | Phosphodiesterase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-05 | — | — | US | claimed |
| EP-0511865-A1 | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-11-04 | — | — | EP | claimed |
| EP-0511865-B1 | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents | AMERICAN HOME PROD (US) | 1997-01-29 | — | — | EP | disclosed |
| US-5250700-A | Phosphodiesterase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |
| US-5191084-A | PHENYL PYRAZOLIDINONES AS BRONCHODILATORS AND ANTI-INFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-03-02 | — | — | US | disclosed |
| EP-0511865-A1 | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-11-04 | — | — | EP | disclosed |