Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27451598 | 1.00 | CHRM2 (0.49) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL20797832 | 0.88 | CHRM2 (0.55) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL20811168 | 0.88 | CHRM2 (0.55) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL24853529 | 0.81 | CHRM2 (0.45) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL22097774 | 0.81 | CHRM2 (0.45) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL28611280 | 0.81 | CHRM2 (0.45) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL10077401 | 0.80 | ACHE (0.55) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL11144165 | 0.80 | ACHE (0.55) | CHRM2CHRM4CHRM5MAPTACHE | |
| Hydrochloric Acid SCHEMBL28618395 | 0.80 | CHRM2 (0.47) | CHRM2CHRM4CHRM5MAPTACHE | |
| SCHEMBL21266577 | 0.79 | CHRM2 (0.65) | CHRM2CHRM4CHRM5SIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417698-B1 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AG (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5374731-A | Treatment of high blood pressure, congestive heart failure and viral disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| EP-0417698-A2 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | disclosed |