Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.51 |
| ▸ | F10 | P00742 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948731 | 0.91 | ITGB3 (0.58) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8948628 | 0.90 | ITGB3 (0.57) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8948633 | 0.85 | ITGB3 (0.75) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8948638 | 0.85 | ITGB3 (0.75) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8948635 | 0.85 | ITGB3 (0.75) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8312623 | 0.84 | ITGB3 (0.55) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8317191 | 0.83 | ITGB3 (0.62) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL8858122 | 0.81 | ITGB3 (0.48) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7307345 | 0.81 | ITGB3 (0.47) | ITGB3ITGA2BF10SIGMAR1 | |
| SCHEMBL8948798 | 0.81 | ITGB3 (0.72) | ITGB3ITGA2BPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | claimed |
| EP-0727425-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-08-21 | — | — | EP | claimed |
| JP-8253477-A | — | — | None | — | — | JP | disclosed |
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | disclosed |
| JP-H08253477-A | ADHESION RECEPTOR ANTAGONIST | MERCK PATENT GMBH | 1996-10-01 | — | — | JP | disclosed |
| EP-0727425-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-08-21 | — | — | EP | disclosed |