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Sugi Predict / Compounds / SCHEMBL7301626

SCHEMBL7301626

SCHEMBL7301626

CC(C)C(NC(=O)CN(C(=O)[C@@H](NC(=O)c1ccc(C(=O)NCC(=O)OCc2ccccc2)cc1)C(C)C)C1Cc2ccccc2C1)C(=O)C(F)(F)F

nearest known ligand 0.68

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 19/20 0.68
▸ MAPT P10636 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ CTRC Q99895 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7299006 0.90 ELANE (0.56) ELANE
SCHEMBL7301033 0.86 ELANE (0.59) ELANE
SCHEMBL7300428 0.84 ELANE (0.59) ELANE
SCHEMBL7308079 0.81 ELANE (0.53) ELANEMAPTRAB9A
SCHEMBL7442937 0.76 ELANE (0.47) ELANEMAPT
SCHEMBL7303462 0.75 ELANE (0.57) ELANE
SCHEMBL27278810 0.75 ELANE (0.57) ELANE
SCHEMBL6261618 0.74 ELANE (0.49) ELANEMAPT
SCHEMBL6261622 0.74 ELANE (0.49) ELANEMAPT
SCHEMBL7300501 0.74 ELANE (0.68) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0494071-B1 Trifluoromethylketone tripeptide derivatives FUJISAWA PHARMACEUTICAL CO (JP) 1997-04-16 — — EP disclosed
US-5430025-A Elastase-inhibiting peptides bearing a C-terminal trifluoromethylketone moiety FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-07-04 — — US disclosed
US-5296591-A Enzyme inhibitors FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-03-22 — — US disclosed
EP-0494071-A2 Trifluoromethylketone tripeptide derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-07-08 — — EP disclosed