Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 4/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | LAP3 | P28838 | 2/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290790 | 0.87 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7293225 | 0.85 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7301022 | 0.85 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7290892 | 0.84 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7301837 | 0.81 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31506428 | 0.81 | ATM (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22305235 | 0.81 | ATM (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2059435 | 0.81 | ATM (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8910000 | 0.81 | ATM (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5541452 | 0.81 | ATM (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |