Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S | Q13698 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | SCN1A | P35498 | 1/20 | 0.44 |
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294678 | 0.85 | CACNA1S (0.52) | CACNA1SCYP3A4ALDH1A1TSHRABCB11 | |
| SCHEMBL7301878 | 0.81 | CACNA1S (0.49) | CACNA1SCYP3A4ALDH1A1TSHRABCB11 | |
| Fumaric Acid SCHEMBL10675579 | 0.80 | MEN1 (0.41) | CACNA1SALDH1A1MEN1KMT2ACACNA1B | |
| Fumaric Acid SCHEMBL10675566 | 0.80 | MEN1 (0.41) | CACNA1SALDH1A1MEN1KMT2ACACNA1B | |
| Fumaric Acid SCHEMBL10674238 | 0.79 | KDM4E (0.41) | CACNA1SCYP3A4LMNALSSMEN1 | |
| Fumaric Acid SCHEMBL10674260 | 0.79 | KDM4E (0.41) | CACNA1SCYP3A4LMNALSSMEN1 | |
| SCHEMBL7288133 | 0.78 | CACNA1S (0.50) | CACNA1SCYP3A4ALDH1A1TSHRABCB11 | |
| Oxalic Acid SCHEMBL9749896 | 0.78 | CYP3A4 (0.52) | CYP3A4ALDH1A1TSHRLMNAHTT | |
| Hydrochloric Acid SCHEMBL9749749 | 0.78 | BCHE (0.43) | CACNA1SCYP3A4ALDH1A1TSHRABCB11 | |
| SCHEMBL7290621 | 0.77 | MEN1 (0.50) | ALDH1A1LMNAHTTLSSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233291-A1 | 2-ARYLBENZOTHIAZINE DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1987-08-26 | — | — | EP | disclosed |
| US-4584300-A | Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1986-04-22 | — | — | US | disclosed |
| EP-0116368-A1 | Benzothiazine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-22 | — | — | EP | disclosed |