Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S | Q13698 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 2/20 | 0.43 |
| ▸ | SCN1A | P35498 | 2/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | SCN4A | P35499 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288133 | 0.97 | CACNA1S (0.50) | CACNA1SKCNH2CYP3A4TSHRLMNA | |
| SCHEMBL7294678 | 0.85 | CACNA1S (0.52) | CACNA1SKCNH2CYP3A4TSHRLMNA | |
| SCHEMBL7291474 | 0.84 | CACNA1S (0.46) | CACNA1SKCNH2CYP3A4TSHRLMNA | |
| SCHEMBL7288046 | 0.82 | CACNA1S (0.47) | CACNA1SKCNH2CYP3A4TSHRLMNA | |
| SCHEMBL10856668 | 0.81 | CACNA1S (0.46) | CACNA1SKCNH2CYP3A4TSHRLMNA | |
| SCHEMBL7301681 | 0.81 | CACNA1S (0.48) | CACNA1SKCNH2CYP3A4TSHRLMNA | |
| SCHEMBL10860217 | 0.81 | CACNA1S (0.45) | CACNA1SKCNH2CYP3A4TSHRLMNA | |
| SCHEMBL7282222 | 0.80 | MAPT (0.46) | KCNH2CYP3A4LMNAHTTMEN1 | |
| SCHEMBL7280040 | 0.78 | CYP2D6 (0.52) | CACNA1SKCNH2CYP3A4TSHRLMNA | |
| SCHEMBL7122984 | 0.76 | F10 (0.54) | CACNA1SHRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4584300-A | Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1986-04-22 | — | — | US | disclosed |
| EP-0116368-A1 | Benzothiazine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1984-08-22 | — | — | EP | disclosed |