Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 18/20 | 0.70 |
| ▸ | MMP13 | P45452 | 15/20 | 0.58 |
| ▸ | MMP9 | P14780 | 14/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 8/20 | 0.58 |
| ▸ | MMP2 | P08253 | 6/20 | 0.55 |
| ▸ | MMP3 | P08254 | 5/20 | 0.55 |
| ▸ | MMP8 | P22894 | 4/20 | 0.55 |
| ▸ | MMP14 | P50281 | 4/20 | 0.55 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.50 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303077 | 0.89 | MMP1 (0.72) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7307783 | 0.89 | MMP1 (0.66) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7311958 | 0.88 | MMP1 (0.63) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7301052 | 0.88 | MMP1 (0.54) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7311291 | 0.87 | MMP1 (0.64) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7299271 | 0.87 | MMP1 (0.66) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7309090 | 0.85 | MMP1 (0.80) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7301387 | 0.84 | MMP1 (0.79) | MMP1MMP13MMP9ADAM17MMP2 | |
| SCHEMBL7307897 | 0.82 | MMP1 (1.00) | MMP1MMP13MMP9MMP2MMP3 | |
| SCHEMBL7308211 | 0.82 | MMP1 (0.76) | MMP1MMP13MMP9ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |