Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 18/20 | 0.64 |
| ▸ | MMP1 | P03956 | 8/20 | 0.61 |
| ▸ | MMP2 | P08253 | 8/20 | 0.52 |
| ▸ | TARS1 | P26639 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301778 | 1.00 | MMP13 (0.64) | MMP13MMP1MMP2TARS1 | |
| SCHEMBL7301867 | 0.86 | MMP13 (0.80) | MMP13MMP1MMP2 | |
| SCHEMBL7301855 | 0.86 | MMP13 (0.80) | MMP13MMP1MMP2 | |
| SCHEMBL7308976 | 0.85 | MMP13 (0.58) | MMP13MMP1MMP2TARS1 | |
| Hydrochloric Acid SCHEMBL7308854 | 0.85 | MMP13 (0.79) | MMP13MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL7308866 | 0.85 | MMP13 (0.79) | MMP13MMP1MMP2 | |
| SCHEMBL7308959 | 0.85 | MMP13 (0.58) | MMP13MMP1MMP2TARS1 | |
| SCHEMBL7301636 | 0.83 | MMP13 (0.57) | MMP13MMP1MMP2TARS1 | |
| SCHEMBL7308292 | 0.78 | MMP13 (0.61) | MMP13MMP1MMP2TARS1 | |
| SCHEMBL7303925 | 0.76 | MMP13 (0.76) | MMP13MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |