Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301947 | 1.00 | MEN1 (0.45) | MEN1KMT2ATGM2SMN1; SMN2LMNA | |
| SCHEMBL9458325 | 0.91 | MEN1 (0.47) | MEN1KMT2ATGM2SMN1; SMN2LMNA | |
| SCHEMBL7291852 | 0.89 | MEN1 (0.54) | MEN1KMT2ATGM2SMN1; SMN2LMNA | |
| SCHEMBL16862506 | 0.88 | MEN1 (0.46) | MEN1KMT2ATGM2SMN1; SMN2LMNA | |
| SCHEMBL7271033 | 0.87 | KMT2A (0.52) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9457600 | 0.86 | ALDH1A1 (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL9457593 | 0.86 | ALDH1A1 (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL9458321 | 0.85 | MEN1 (0.43) | MEN1KMT2ATGM2SMN1; SMN2LMNA | |
| SCHEMBL7291857 | 0.85 | MEN1 (0.46) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7385326 | 0.83 | MEN1 (0.43) | MEN1KMT2ATGM2SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164388-A | Hypotensive agents, treatment of congestive heart failure | ABBOTT LABORATORIES (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0439556-A4 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | — | 1991-10-30 | — | — | EP | disclosed |
| EP-0439556-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| WO-1990004917-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-05-17 | — | — | WO | disclosed |
| EP-0365992-A1 | Heterocyclic peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-05-02 | — | — | EP | disclosed |