Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.49 |
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 7/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293457 | 0.92 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7299783 | 0.91 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7299761 | 0.90 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7295128 | 0.89 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7302103 | 0.87 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7293178 | 0.87 | BACE1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7301635 | 0.86 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7301536 | 0.86 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7302349 | 0.86 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7296543 | 0.85 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | claimed |