Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 12/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | HMGCR | P04035 | 1/20 | 0.38 |
| ▸ | MPEG1 | Q2M385 | 7/20 | 0.38 |
| ▸ | XIAP | P98170 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10576887 | 1.00 | ACHE (0.39) | ACHEBACE1ALOX5PTGS2HMGCR | |
| SCHEMBL10576575 | 1.00 | ACHE (0.39) | ACHEBACE1ALOX5PTGS2HMGCR | |
| SCHEMBL10577585 | 1.00 | ACHE (0.39) | ACHEBACE1ALOX5PTGS2HMGCR | |
| SCHEMBL7298216 | 1.00 | ACHE (0.39) | ACHEBACE1ALOX5PTGS2HMGCR | |
| SCHEMBL10579063 | 0.91 | PDCD4 (0.45) | KDM4EALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL10576730 | 0.91 | PDCD4 (0.45) | KDM4EALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL9327608 | 0.91 | MAPT (0.41) | MAPTKMT2A | |
| SCHEMBL10579069 | 0.91 | PDCD4 (0.45) | KDM4EALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL10575180 | 0.91 | PDCD4 (0.45) | KDM4EALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL10576717 | 0.91 | PDCD4 (0.45) | KDM4EALDH1A1HPGDALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5376676-A | Process of using anti-inflammatory furanones as selective calcium channel inhibitors | ALLERGAN, INC. (US) | 1994-12-27 | — | — | US | disclosed |
| US-5045564-A | Calcium channel antagonists | ALLERGAN, INC. (US) | 1991-09-03 | — | — | US | disclosed |
| EP-0372940-A2 | Anti-inflammatory 2-furanones | ALLERGAN, INC (US) | 1990-06-13 | — | — | EP | disclosed |