Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.33 |
| ▸ | WNT3A | P56704 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CRHBP | P24387 | 2/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7290867 | 0.76 | ITGB2 (0.39) | EGFRITGB2ICAM1ITGALLMNA | |
| SCHEMBL7293462 | 0.75 | HTR2A (0.33) | ITGB2ICAM1ITGAL | |
| SCHEMBL29604730 | 0.72 | ITGB2 (0.44) | EGFRITGB2ICAM1ITGALCTNNB1 | |
| SCHEMBL7290576 | 0.72 | ITGB2 (0.39) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL7294182 | 0.72 | ITGB2 (0.39) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL9584132 | 0.72 | MAP3K14 (0.44) | ITGB2ICAM1ITGALLMNACRHBP | |
| SCHEMBL20858620 | 0.70 | ITGB2 (0.38) | EGFRITGB2ICAM1ITGALCTNNB1 | |
| SCHEMBL7298517 | 0.68 | KMT2A (0.31) | KMT2A | |
| SCHEMBL9583519 | 0.68 | CTNNB1 (0.40) | ITGB2ICAM1ITGALCTNNB1WNT3A | |
| SCHEMBL7300186 | 0.68 | ITGB2 (0.35) | EGFRITGB2ICAM1ITGALLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260444-A | Cardiovascular, hypotensive | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-11-09 | — | — | US | disclosed |
| US-5208245-A | Hypotensive agents | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1993-05-04 | — | — | US | disclosed |
| EP-0460418-A2 | Novel Dihydropyridine derivative | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1991-12-11 | — | — | EP | disclosed |