Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.50 |
| ▸ | GNPAT | O15228 | 1/20 | 0.49 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.49 |
| ▸ | NPY4R | P50391 | 9/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.49 |
| ▸ | NPY1R | P25929 | 7/20 | 0.49 |
| ▸ | NPY2R | P49146 | 5/20 | 0.49 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2750013 | 0.91 | C3AR1 (0.50) | FOLH1 | |
| SCHEMBL1694411 | 0.91 | C3AR1 (0.50) | FOLH1 | |
| SCHEMBL30294160 | 0.89 | FOLH1 (0.45) | FOLH1GNPATQRFPRNPY4RNPY5R | |
| SCHEMBL30626300 | 0.87 | OPRD1 (0.53) | GNPATQRFPRNPY4RNPY5RNPY1R | |
| SCHEMBL30692729 | 0.87 | GNPAT (0.54) | GNPATQRFPRNPY4RNPY5RNPY1R | |
| SCHEMBL29447211 | 0.87 | GNPAT (0.54) | GNPATQRFPRNPY4RNPY5RNPY1R | |
| SCHEMBL29590419 | 0.87 | QRFPR (0.60) | GNPATQRFPRNPY4RNPY5RNPY1R | |
| SCHEMBL30692724 | 0.86 | OPRD1 (0.53) | GNPATNPY4RNPY5RNPY1RNPY2R | |
| SCHEMBL10829274 | 0.86 | PTGER4 (0.56) | FOLH1GNPATQRFPRNPY4RNPY5R | |
| SCHEMBL10829276 | 0.86 | PTGER4 (0.56) | FOLH1GNPATQRFPRNPY4RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1068586-C | Crystalline, polymorphic form of (S,S,S)-n-(1-[2-carboxy-3-(n2-mesyllysylamino)propyl]-1-cyclopenlylcarbonyl)tyrosine | PFIZER RES & DEV CO N V S A (IE) | 2001-07-18 | — | — | CN | disclosed |
| US-6180665-B1 | HYPOTENSIVE AGENTS; ANGIOTENSIN CONVERTING ENZYME INHIBITOR | PFIZER INC. | 2001-01-30 | — | — | US | disclosed |
| EP-0731787-B1 | CRYSTALLINE, POLYMORPHIC FORM OF (S,S,S)-N-(1-[2-CARBOXY-3-(N2-MESYLLYSYLAMINO)PROPYL]-1-CYCLOPENTYLCARBONYL)TYROSINE | PFIZER LTD (GB) | 1999-01-13 | — | — | EP | disclosed |
| CN-1142816-A | Crystalline, polymorphic form of (S,S,S)-n-(1-[2-carboxy-3-(n2-mesyllysylamino)propyl]-1-cyclopenlylcarbonyl)tyrosine | PFIZER LTD (IE) | 1997-02-12 | — | — | CN | disclosed |
| CN-1031051-C | Cycloalkyl-substituted glutaramide antihypertensive agents | PFIZER (US) | 1996-02-21 | — | — | CN | disclosed |
| US-5362902-A | Diuretics and treatment of cardiovascular disorders | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0358398-B1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE ANTIHYPERTENSIVE AGENTS | Pfizer Limited (GB) | 1993-03-10 | — | — | EP | disclosed |
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| CN-1016778-B | spiro-substituted glutaric acid monoamides | PFIZER LTD (GB) | 1992-05-27 | — | — | CN | disclosed |
| EP-0274234-B1 | SPIRO-SUBSITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1991-09-11 | — | — | EP | disclosed |
| US-5036104-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1991-07-30 | — | — | US | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| US-4975444-A | INHIBITORS OF ANGIORENSIN-CONVERTING ENZYME AS WELL AS A ENDOPEPTIDASE; CARDIOTONIC AGENTS; GLAUCOMA; DIURETICS | PFIZER INC. (US) | 1990-12-04 | — | — | US | disclosed |
| US-4960792-A | HYPOTENSIVE AGENTS | PFIZER INC. (US) | 1990-10-02 | — | — | US | disclosed |
| WO-1990009374-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1990-08-23 | — | — | WO | disclosed |
| CN-1040986-A | The preparation of the glutaramide derivatives of cycloalkyl substituted | PFIZER (US) | 1990-04-04 | — | — | CN | disclosed |
| EP-0358398-A1 | Cycloalkyl-substituted glutaramide antihypertensive agents | Pfizer Limited (GB) | 1990-03-14 | — | — | EP | disclosed |
| EP-0274234-A2 | Spiro-subsituted glutaramide diuretic agents | Pfizer Limited (GB) | 1988-07-13 | — | — | EP | disclosed |
| CN-87107371-A | The glutaramide diuretic agents of spiral shell-replacement | — | 1988-07-06 | — | — | CN | disclosed |