Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RARG | P13631 | 9/20 | 0.47 |
| ▸ | RARB | P10826 | 8/20 | 0.47 |
| ▸ | RARA | P10276 | 7/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302403 | 1.00 | ALDH1A1 (0.53) | ALDH1A1POLBTDP1GLAL3MBTL1 | |
| SCHEMBL20853874 | 0.85 | AKR1C3 (0.58) | ALDH1A1POLBTDP1GLAAKR1C3 | |
| SCHEMBL28915528 | 0.85 | AKR1C3 (0.58) | ALDH1A1POLBTDP1GLAAKR1C3 | |
| SCHEMBL7316708 | 0.84 | ALDH1A1 (0.51) | ALDH1A1TDP1MAPTRARGRARB | |
| SCHEMBL7316713 | 0.84 | ALDH1A1 (0.51) | ALDH1A1TDP1MAPTRARGRARB | |
| SCHEMBL5606469 | 0.83 | ALDH1A1 (0.50) | ALDH1A1AKR1C3CYP2C9CA1CA2 | |
| SCHEMBL7302575 | 0.79 | KMT2A (0.52) | ALDH1A1TDP1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL7302569 | 0.79 | KMT2A (0.52) | ALDH1A1TDP1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL7312808 | 0.77 | AKR1C3 (0.53) | ALDH1A1POLBTDP1GLAL3MBTL1 | |
| SCHEMBL7312807 | 0.77 | AKR1C3 (0.53) | ALDH1A1POLBTDP1GLAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901653-A | Novel amide derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof | 株式会社LG化学 | 2022-08-12 | — | — | CN | disclosed |
| EP-0656349-B1 | Amidinophenol derivatives having phospholipase A2 inhibitory activity | ONO PHARMACEUTICAL CO (JP) | 1998-04-08 | — | — | EP | disclosed |
| US-5622984-A | INHIBITORS OF PHOSPHOLIPASE, VARIOUS PROTEASES | ONO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1997-04-22 | — | — | US | disclosed |
| US-5614555-A | Amidinophenol derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0588655-B1 | Amidinophenol derivatives | ONO PHARMACEUTICAL CO (JP) | 1996-12-04 | — | — | EP | disclosed |
| US-5514713-A | Amidinophenol derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-05-07 | — | — | US | disclosed |
| US-5432178-A | Substituted benzoic acid esters; use to prevent or treat inflammatory diseases, allergic diseases, disseminated intravascular coagulation, pancreatitis or multiple organ failure | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-07-11 | — | — | US | disclosed |
| EP-0656349-A1 | Amidinophenol derivatives having phospholipase A2 inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-06-07 | — | — | EP | disclosed |
| EP-0588655-A1 | Amidinophenol derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |