Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.44 |
| ▸ | BACE1 | P56817 | 3/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307304 | 0.91 | KLK5 (0.52) | KLK5ATMITGB3ITGA2BBCHE | |
| SCHEMBL7314764 | 0.91 | KLK5 (0.52) | KLK5ATMITGB3ITGA2BBCHE | |
| SCHEMBL8955028 | 0.91 | KLK5 (0.52) | KLK5ATMITGB3ITGA2BBCHE | |
| SCHEMBL7312642 | 0.90 | KLK5 (0.52) | KLK5ATMBCHEPTPN1PSEN1 | |
| SCHEMBL7309398 | 0.89 | KLK5 (0.61) | KLK5ATMBCHEPSEN1PSEN2 | |
| SCHEMBL7303561 | 0.89 | KLK5 (0.61) | KLK5ATMBCHEPSEN1PSEN2 | |
| SCHEMBL7304740 | 0.89 | KLK5 (0.51) | KLK5ATMITGB3ITGA2BBCHE | |
| SCHEMBL8955077 | 0.87 | KLK5 (0.49) | KLK5ATMITGB3ITGA2BBCHE | |
| SCHEMBL7309371 | 0.87 | KLK5 (0.46) | KLK5ATMITGB3ITGA2BBCHE | |
| SCHEMBL8955018 | 0.87 | KLK5 (0.46) | KLK5ATMITGB3ITGA2BBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559256-A | Aminediol protease inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1996-09-24 | — | — | US | disclosed |
| EP-0580402-A2 | Aminediol protease inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1994-01-26 | — | — | EP | disclosed |