Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.47 |
| ▸ | EDNRB | P24530 | 3/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303081 | 0.91 | LMNA (0.48) | EDNRAEDNRBESR1ALDH1A1LMNA | |
| SCHEMBL7303662 | 0.89 | EDNRA (0.55) | EDNRAEDNRBESR1 | |
| SCHEMBL7297111 | 0.88 | EDNRA (0.57) | EDNRAEDNRB | |
| SCHEMBL7303175 | 0.88 | MEN1 (0.51) | EDNRAEDNRBESR1ALDH1A1LMNA | |
| SCHEMBL7296548 | 0.85 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL7306773 | 0.84 | EDNRA (0.57) | EDNRAEDNRB | |
| SCHEMBL7302591 | 0.82 | EDNRA (0.45) | EDNRAEDNRBESR1MEN1KMT2A | |
| SCHEMBL7293909 | 0.79 | ESR1 (0.44) | EDNRAEDNRBESR1ALDH1A1LMNA | |
| SCHEMBL6783690 | 0.78 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL627598 | 0.76 | EDNRA (0.70) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |