Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303055 | 0.93 | GPR119 (0.47) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9877370 | 0.87 | GPR119 (0.45) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9877420 | 0.86 | GPR119 (0.45) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7295019 | 0.82 | PDE3B (0.60) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9178937 | 0.81 | PDE3B (0.61) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7294767 | 0.81 | PDE3B (0.60) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9180434 | 0.79 | PDE3B (0.61) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL16157203 | 0.75 | PDE3B (0.67) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL9516148 | 0.75 | PDE3B (0.67) | PDE3BPDE3AABCB11MAOAADORA2A | |
| SCHEMBL7295007 | 0.74 | PDE3B (0.51) | PDE3BPDE3AABCB11MAOAADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |