⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17473471 | 0.98 | L3MBTL1 (0.35) | — | |
| SCHEMBL27895274 | 0.77 | — | — | |
| SCHEMBL30016448 | 0.77 | — | — | |
| SCHEMBL27072050 | 0.77 | — | — | |
| SCHEMBL27056676 | 0.77 | — | — | |
| SCHEMBL16921050 | 0.76 | — | — | |
| SCHEMBL28452274 | 0.76 | — | — | |
| SCHEMBL16921038 | 0.76 | — | — | |
| SCHEMBL15492418 | 0.76 | — | — | |
| SCHEMBL19245100 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478085-B | Method for resolution synthesis of argatroban intermediate (2R, 4R) -4-methyl-2-ethyl piperidine formate | 浙江康聚药业有限公司 | 2023-11-07 | — | — | CN | claimed |
| CN-116478085-A | Method for resolution synthesis of argatroban intermediate (2R, 4R) -4-methyl-2-ethyl piperidine formate | 浙江康聚药业有限公司 | 2023-07-25 | — | — | CN | claimed |
| CN-106699638-B | Preparation method of argatroban intermediate | 天津药物研究院药业有限责任公司 | 2019-06-25 | — | — | CN | claimed |
| CN-108047125-A | The preparation method of one kind (2R, 4R) -4- methyl piperidine -2- Ethyl formate compounds | 北京沃邦医药科技有限公司 | 2018-05-18 | — | — | CN | claimed |
| CN-118684618-A | Argatroban middle Process for the preparation of intermediates | 山东新时代药业有限公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-116478085-B | Method for resolution synthesis of argatroban intermediate (2R, 4R) -4-methyl-2-ethyl piperidine formate | 浙江康聚药业有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-116478085-A | Method for resolution synthesis of argatroban intermediate (2R, 4R) -4-methyl-2-ethyl piperidine formate | 浙江康聚药业有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116217466-A | Preparation method of argatroban intermediate 4-methyl-2-ethyl piperidine formate | 山东新时代药业有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-109761886-B | Resolution method of argatroban starting material isomer impurities | 北京悦康科创医药科技股份有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-109734653-B | Resolution method of argatroban starting material isomer impurities | 北京悦康科创医药科技股份有限公司 | 2020-07-14 | — | — | CN | disclosed |
| CN-109761885-B | Resolution method of argatroban isomer impurities | 北京悦康科创医药科技股份有限公司 | 2020-06-26 | — | — | CN | disclosed |
| US-10385020-B2 | Process intermediates and methods for the preparation of process intermediates for the synthesis of argatroban monohydrate | LUNDBECK PHARMACEUTICALS ITALY S.P.A. (IT) | 2019-08-20 | — | — | US | disclosed |
| US-4131673-A | INHIBITION AND SUPPRESSION OF THROMBOSIS IN MAMMALS | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1978-12-26 | — | — | US | disclosed |
| US-4117127-A | INHIBITION AND SUPPRESSION OF THROMBOSIS | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JP) | 1978-09-26 | — | — | US | disclosed |
| US-4101653-A | ANTITHROMBOSIS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1978-07-18 | — | — | US | disclosed |
| US-4097472-A | INHIBITION AND SUPRESSION OF THROMBOSIS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1978-06-27 | — | — | US | disclosed |
| US-4093712-A | ANTITHROMBOGENIC AGENTS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1978-06-06 | — | — | US | disclosed |
| US-4073913-A | INHIBITION AND SUPPRESSION OF THROMBIN | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1978-02-14 | — | — | US | disclosed |
| US-4072757-A | SUPPRESSION OF THROMBOSIS | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1978-02-07 | — | — | US | disclosed |
| US-4066773-A | ANTITHROMBOSIS | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JA) | 1978-01-03 | — | — | US | disclosed |