Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300275 | 0.96 | AGTR2 (0.41) | AGTR2AGTR1 | |
| SCHEMBL7306526 | 0.93 | AGTR2 (0.39) | AGTR2AGTR1 | |
| SCHEMBL7310133 | 0.92 | AGTR2 (0.44) | AGTR2AGTR1 | |
| SCHEMBL7303443 | 0.92 | AGTR2 (0.39) | AGTR2AGTR1 | |
| SCHEMBL7302104 | 0.90 | AGTR2 (0.41) | AGTR2AGTR1 | |
| SCHEMBL7306339 | 0.90 | AGTR2 (0.36) | AGTR2AGTR1 | |
| SCHEMBL7312844 | 0.88 | AGTR2 (0.41) | AGTR2AGTR1 | |
| SCHEMBL7300928 | 0.88 | AGTR2 (0.47) | AGTR2AGTR1 | |
| SCHEMBL7302537 | 0.85 | AGTR2 (0.44) | AGTR2 | |
| SCHEMBL7306149 | 0.85 | AGTR2 (0.44) | AGTR2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5310927-A | Hypotensive agents; cognition activators; imidazolyl-2-aryl derivatives | GLAXO GROUP LIMITED (GB) | 1994-05-10 | — | — | US | claimed |
| EP-0514193-A1 | N-linked imidazolyl-methyl benzofuran derivatives with antihypotensive activity | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | claimed |
| EP-0514193-A1 | N-linked imidazolyl-methyl benzofuran derivatives with antihypotensive activity | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | disclosed |