SCHEMBL7303538

SCHEMBL7303538

COC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)C1Cc2ccccc2C1

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.49
ALOX5 P09917 1/20 0.47
PREP P48147 10/20 0.47
ALDH1A1 P00352 1/20 0.45
CYP3A4 P08684 1/20 0.45
TSHR P16473 1/20 0.45
HSD11B1 P28845 2/20 0.43
POLB P06746 1/20 0.43
PDK2 Q15119 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7303542 1.00 F2 (0.49) F2ALOX5PREPALDH1A1CYP3A4
SCHEMBL7295174 0.92 F2 (0.55) F2ALOX5PREPALDH1A1CYP3A4
SCHEMBL7302711 0.91 F2 (0.59) F2ALOX5PREPALDH1A1CYP3A4
SCHEMBL7294184 0.84 PREP (0.69) PREP
SCHEMBL9047977 0.83 PREP (0.62) F2PREP
SCHEMBL9047963 0.83 PREP (0.62) F2PREP
SCHEMBL7301169 0.83 PREP (0.70) PREP
SCHEMBL7298505 0.82 PREP (0.71) F2PREP
SCHEMBL7298496 0.82 PREP (0.71) F2PREP
SCHEMBL7302878 0.81 PREP (0.68) PREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0372484-B1 Condensed benzene derivative ZERIA PHARM CO LTD (JP) 1994-10-26 EP disclosed
US-5028604-A Cognition Activators ZERIA PHARMACEUTICAL CO., LTD. (JP) 1991-07-02 US disclosed
EP-0372484-A2 Condensed benzene derivative ZERIA PHARMACEUTICAL CO., LTD. (JP) 1990-06-13 EP disclosed