Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.51 |
| ▸ | NPY2R | P49146 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 12/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.50 |
| ▸ | PDE4A | P27815 | 5/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10353452 | 0.86 | SMN1; SMN2 (0.81) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL2798028 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL7263634 | 0.79 | KCNH2 (0.73) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL930230 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL2846257 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL11035016 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL6331085 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL7273533 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL8302890 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL11006840 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2KCNH2LMNAMAPTNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020130214-A1 | NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF | 한국과학기술연구원 | 2020-06-25 | — | — | WO | disclosed |
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |
| US-4925845-A | HYPOTENSIVE AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1990-05-15 | — | — | US | disclosed |