Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CETP | P11597 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.46 |
| ▸ | CEPT1 | Q9Y6K0 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2137383 | 0.82 | DHODH (0.54) | DHODHMTNR1AMTNR1BKDM4EHPGD | |
| SCHEMBL9126988 | 0.78 | DHODH (0.70) | DHODHMTNR1AMTNR1BKDM4EHPGD | |
| SCHEMBL30594910 | 0.75 | DHODH (0.54) | DHODHMTNR1AMTNR1BKDM4EHPGD | |
| SCHEMBL17254731 | 0.74 | MAPT (0.72) | KDM4EHPGDALDH1A1MAPTKMT2A | |
| SCHEMBL121400 | 0.74 | DHODH (0.94) | DHODHMTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL16383807 | 0.73 | DHODH (0.76) | DHODHMTNR1AMTNR1BKDM4ECETP | |
| SCHEMBL29728160 | 0.72 | DHODH (0.56) | DHODHMTNR1AMTNR1BKDM4EHPGD | |
| SCHEMBL31711580 | 0.72 | DHODH (0.60) | DHODHMTNR1AMTNR1BKDM4EHPGD | |
| SCHEMBL505539 | 0.72 | DHODH (1.00) | DHODHMTNR1AMTNR1BKDM4ECETP | |
| SCHEMBL31737306 | 0.71 | DHODH (0.72) | DHODHMTNR1AMTNR1BCETPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450420-B1 | Dihydropyridines substituted by heterocycles, process for their preparation and their use in medicaments | BAYER AG (DE) | 1994-09-21 | — | — | EP | disclosed |
| EP-0450420-A2 | Dihydropyridines substituted by heterocycles, process for their preparation and their use in medicaments | BAYER AG (DE) | 1991-10-09 | — | — | EP | disclosed |