Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CPA1 | P15085 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304664 | 1.00 | ALDH1A1 (0.61) | ALDH1A1CYP2C19LMNAMAPTCPA1 | |
| SCHEMBL7303616 | 0.89 | ALDH1A1 (0.59) | ALDH1A1CYP2C19LMNAMAPTCPA1 | |
| SCHEMBL4125403 | 0.77 | ALDH1A1 (0.60) | ALDH1A1CYP2C19LMNAMAPTHTT | |
| SCHEMBL7296441 | 0.73 | CA1 (0.43) | ALDH1A1CYP2C19LMNAMAPTFPR2 | |
| SCHEMBL1661029 | 0.72 | ALDH1A1 (0.54) | ALDH1A1CYP2C19LMNAMAPTHTT | |
| SCHEMBL5518745 | 0.72 | ALDH1A1 (0.63) | ALDH1A1CYP2C19LMNAMAPTHTT | |
| SCHEMBL5525324 | 0.72 | ALDH1A1 (0.63) | ALDH1A1CYP2C19LMNAMAPTHTT | |
| SCHEMBL7042336 | 0.72 | TP53 (0.56) | HTTFPR2LDHAHIF1APDE4A | |
| SCHEMBL28107955 | 0.71 | EPHX1 (0.62) | ALDH1A1CYP2C19LMNAFPR2LDHA | |
| SCHEMBL18255547 | 0.71 | HIF1A (0.53) | FPR2LDHAHIF1APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444083-A | DOPAMINE AGONIST FOR TREATING OR PREVENTION OF HYPERTENSION OR HEART FAILURE | EISAI CO., LTD. (JP) | 1995-08-22 | — | — | US | disclosed |
| EP-0381235-A2 | Pyrrolidine compound and pharmaceutical use | Eisai Co., Ltd. (JP) | 1990-08-08 | — | — | EP | disclosed |