Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.67 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.67 |
| ▸ | CCKBR | P32239 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.67 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.67 |
| ▸ | CACNA1F | O60840 | 9/20 | 0.57 |
| ▸ | CACNA1D | Q01668 | 9/20 | 0.57 |
| ▸ | CACNA1S | Q13698 | 9/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 9/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305006 | 1.00 | ADORA3 (0.67) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| SCHEMBL7300791 | 0.92 | ADORA3 (0.81) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| SCHEMBL7300796 | 0.92 | ADORA3 (0.81) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| SCHEMBL7380464 | 0.90 | CACNA1F (0.72) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| Hydrochloric Acid SCHEMBL11180647 | 0.89 | CACNA1F (0.71) | ADORA3NR1I2NR3C1ABCB1TBXA2R | |
| SCHEMBL3940339 | 0.88 | CACNA1F (0.71) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL3032197 | 0.88 | CACNA1F (0.71) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| Hydrochloric Acid SCHEMBL9805027 | 0.87 | CACNA1F (0.70) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| Hydrochloric Acid SCHEMBL9374052 | 0.87 | CACNA1F (0.70) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C | |
| Hydrochloric Acid SCHEMBL9374064 | 0.87 | CACNA1F (0.70) | ADORA3CACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101068546-A | Pharmaceutical composition, process for producing the same, and method for stabilizing dihydropyridine compound in pharmaceutical composition | EISAI R&D MAN CO LTD (JP) | 2007-11-07 | — | — | CN | disclosed |
| EP-0747357-B1 | Dihydropyridine NPY antagonists: piperidine derivatives | BRISTOL MYERS SQUIBB CO (US) | 2002-01-09 | — | — | EP | disclosed |
| US-5668151-A | USEFUL AS ANOREXIGENIC AGENTS IN PROMOTING WEIGHT LOSS AND TREATING EATING DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| US-5635503-A | TREATMENT OF EATING DISORDERS, PROMOTING WEIGHT LOSS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-06-03 | — | — | US | disclosed |
| EP-0747356-A1 | Dihydropyridine NPY antagonists: piperazine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0747378-A1 | Dihydropyridine NPY antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0747357-A2 | Dihydropyridine NPY antagonists: piperidine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |
| US-5554621-A | Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| EP-0447812-B1 | Use of a dihydropyridine to improve the inner ear blood circulation | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-01-10 | — | — | EP | disclosed |
| US-5258393-A | Vasodilation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-11-02 | — | — | US | disclosed |
| EP-0296553-B1 | PHARMACEUTICAL COMPOSITION FOR PERCUTANEOUS DRUG ABSORPTION AND PERCUTANEOUS DRUG ABSORPTION PROMOTER | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-04-14 | — | — | EP | disclosed |
| US-5160734-A | Complex with polyoxyethylene-polyoxypropylene copolymer | AMERICAN CYANAMID COMPANY (US) | 1992-11-03 | — | — | US | disclosed |
| EP-0317780-B1 | SUSTAINED (CONTROLLED) RELEASE DELIVERY SYSTEM FOR SUBSTITUTED DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS | AMERICAN CYANAMID COMPANY (US) | 1992-05-20 | — | — | EP | disclosed |
| EP-0447812-A2 | Use of a dihydropyridine to improve the inner ear blood circulation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-09-25 | — | — | EP | disclosed |
| EP-0317780-A1 | Sustained (controlled) release delivery system for substituted dihydropyridine calcium channel blockers | AMERICAN CYANAMID COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0296553-A2 | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-12-28 | — | — | EP | disclosed |
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |