Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5151685 | 0.78 | ADORA2A (0.33) | MAPTKDM4EGAAALDH1A1 | |
| SCHEMBL27891097 | 0.74 | PKM (0.34) | PKMMAPTKDM4EGAACDK8 | |
| SCHEMBL19313228 | 0.74 | PKM (0.44) | PKMMAPTKDM4EGAACDK8 | |
| SCHEMBL10916970 | 0.73 | GAA (0.30) | GAA | |
| SCHEMBL5961561 | 0.71 | PKM (0.46) | PKMMAPTKDM4EGAACDK8 | |
| SCHEMBL28619659 | 0.67 | KDM4E (0.49) | MAPTKDM4EGAALMNA | |
| SCHEMBL2467004 | 0.66 | — | — | |
| SCHEMBL34154 | 0.66 | — | — | |
| SCHEMBL11057028 | 0.66 | GAA (0.37) | MAPTKDM4EGAAALDH1A1CYP2C19 | |
| Hydrochloric Acid SCHEMBL11477370 | 0.64 | GAA (0.56) | PKMMAPTKDM4EGAACDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981037-A | Pyrazolopyrimidine PI3K inhibitor compounds and methods of use | GENENTECH INC | 2011-02-23 | — | — | CN | disclosed |
| EP-0636626-A1 | Pyrazolopyrimidine Derivatives | LABORATOIRES GLAXO SA (FR) | 1995-02-01 | — | — | EP | disclosed |