Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318475 | 0.89 | PDE3B (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7311520 | 0.88 | PDE3B (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7316932 | 0.87 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7319496 | 0.84 | PDE3B (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7310656 | 0.83 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7317933 | 0.83 | PDE3B (0.44) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10671368 | 0.83 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10675655 | 0.83 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10665244 | 0.82 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7317927 | 0.82 | PDE3B (0.43) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761416-A | ENZYME INHIBITORS, INOTROPIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-02 | — | — | US | disclosed |
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0254327-A2 | N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl) oxyalkylamides and related compounds | SYNTEX (U.S.A.) INC. (US) | 1988-01-27 | — | — | EP | disclosed |