Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 19/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 19/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 19/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 19/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10651364 | 0.89 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7320897 | 0.89 | PDE3B (0.59) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10671368 | 0.89 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7319882 | 0.88 | PDE3B (0.54) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7308913 | 0.86 | PDE3B (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10650650 | 0.85 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10647172 | 0.84 | PDE3B (0.58) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7305463 | 0.83 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7316720 | 0.83 | PDE3B (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7318809 | 0.83 | PDE4A (0.85) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761416-A | ENZYME INHIBITORS, INOTROPIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-02 | — | — | US | disclosed |
| US-4739056-A | ENZYME INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0254327-A2 | N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl) oxyalkylamides and related compounds | SYNTEX (U.S.A.) INC. (US) | 1988-01-27 | — | — | EP | disclosed |