Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | NPY1R | P25929 | 1/20 | 0.78 |
| ▸ | NPY2R | P49146 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116038 | 0.96 | LMNA (0.76) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL6795295 | 0.93 | MAPT (0.75) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL10967326 | 0.87 | LMNA (1.00) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL1373314 | 0.87 | LMNA (0.80) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7280593 | 0.84 | MAPT (0.75) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL10970095 | 0.84 | MAPT (1.00) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7308328 | 0.84 | LMNA (0.56) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL9815953 | 0.84 | LMNA (0.92) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL10370953 | 0.83 | MAPT (0.78) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7328478 | 0.83 | LMNA (0.72) | LMNANPY1RNPY2RMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |