Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 3/20 | 0.39 |
| ▸ | HSPA5 | P11021 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL7309260 | 0.88 | MME (0.47) | MEN1KMT2AL3MBTL1NPSR1MME | |
| Lithium Ion SCHEMBL7304536 | 0.84 | MME (0.42) | MEN1KMT2AL3MBTL1NPSR1MME | |
| SCHEMBL7298742 | 0.77 | MME (0.46) | MEN1KMT2AL3MBTL1NPSR1MME | |
| SCHEMBL7305542 | 0.76 | LMNA (0.53) | NPSR1NPC1LMNASMN1; SMN2MAPT | |
| SCHEMBL7298727 | 0.76 | MEN1 (0.56) | MEN1KMT2APOLBESR2L3MBTL1 | |
| SCHEMBL7305757 | 0.68 | MEN1 (0.63) | MEN1KMT2APOLBESR2L3MBTL1 | |
| SCHEMBL7310616 | 0.67 | KMT2A (0.71) | MEN1KMT2APOLBESR2L3MBTL1 | |
| SCHEMBL7301785 | 0.64 | LMNA (0.52) | NPSR1NPC1LMNASMN1; SMN2MAPT | |
| SCHEMBL7308785 | 0.64 | MME (0.44) | NPSR1MMENPC1PDE5ALMNA | |
| SCHEMBL7298781 | 0.61 | MME (0.55) | MMEHSPA5PDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636630-B1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON SPA (IT) | 1999-04-28 | — | — | EP | disclosed |
| US-5438046-A | Enzyme inhibitors | ZAMBON GROUP S.P.A. (IT) | 1995-08-01 | — | — | US | disclosed |
| EP-0636630-A1 | N-heteroaryl substituted derivatives of propanamide useful in the treatment of cardiovascular diseases | ZAMBON GROUP S.p.A. (IT) | 1995-02-01 | — | — | EP | disclosed |