Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 5/20 | 0.52 |
| ▸ | ACE | P12821 | 9/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.50 |
| ▸ | CTSG | P08311 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20484733 | 0.90 | LMNA (0.53) | PREPELANEACEACE2CTSG | |
| SCHEMBL3471466 | 0.90 | LMNA (0.53) | PREPELANEACEACE2CTSG | |
| SCHEMBL7362814 | 0.90 | LMNA (0.53) | PREPELANEACEACE2CTSG | |
| SCHEMBL18619558 | 0.89 | ACE (0.62) | PREPACEACE2MEN1KMT2A | |
| SCHEMBL20485168 | 0.89 | ACE (0.62) | PREPACEACE2MEN1KMT2A | |
| SCHEMBL20484538 | 0.88 | PREP (0.53) | PREPELANEACEACE2CTSG | |
| SCHEMBL20484656 | 0.88 | PREP (0.53) | PREPELANEACEACE2CTSG | |
| SCHEMBL20484654 | 0.88 | CCR1 (0.57) | PREPELANEACEACE2CTSG | |
| SCHEMBL20484539 | 0.88 | PREP (0.53) | PREPELANEACEACE2CTSG | |
| SCHEMBL22798260 | 0.88 | CCR1 (0.57) | PREPELANEACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494071-B1 | Trifluoromethylketone tripeptide derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-04-16 | — | — | EP | disclosed |
| US-5430025-A | Elastase-inhibiting peptides bearing a C-terminal trifluoromethylketone moiety | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5296591-A | Enzyme inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0494071-A2 | Trifluoromethylketone tripeptide derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-08 | — | — | EP | disclosed |