Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 8/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.41 |
| ▸ | F10 | P00742 | 8/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7308602 | 0.95 | ITGB3 (0.52) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7313444 | 0.95 | ITGB3 (0.49) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7305481 | 0.91 | ITGB3 (0.55) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL7316851 | 0.90 | ITGB3 (0.54) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6601671 | 0.89 | ITGB3 (0.51) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6600847 | 0.89 | ITGB3 (0.51) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6601747 | 0.89 | ITGB3 (0.51) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6601822 | 0.88 | ITGB3 (0.64) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6600986 | 0.88 | ITGB3 (0.64) | ITGB3ITGA2BPRSS1PRSS2PRSS3 | |
| SCHEMBL6601484 | 0.88 | ITGB3 (0.64) | ITGB3ITGA2BPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6455529-B1 | OXAZOLIDIN-2-ONE DERIVATIVES; ANTICOAGULANTS; ANTIMETASTASIS, ANTICARCINOGENIC, ANTIISCHEMIC, AND ANTIINFLAMMATORY AGENTS; OSTEOPOROSIS, ARTERIOSCLEROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-09-24 | — | — | US | disclosed |
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |
| EP-0727425-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-08-21 | — | — | EP | disclosed |