Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CKS1B | P61024 | 1/20 | 0.48 |
| ▸ | SKP1 | P63208 | 1/20 | 0.48 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.48 |
| ▸ | YAP1 | P46937 | 3/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | ACACA | Q13085 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326804 | 1.00 | KDM4E (0.53) | KDM4EPKMCKS1BSKP1SKP2 | |
| SCHEMBL7304469 | 0.91 | KDM4E (0.57) | KDM4EPKMCKS1BSKP1SKP2 | |
| SCHEMBL7304465 | 0.91 | KDM4E (0.57) | KDM4EPKMCKS1BSKP1SKP2 | |
| SCHEMBL9326765 | 0.87 | KMT2A (0.55) | CKS1BSKP1SKP2GPR119KMT2A | |
| SCHEMBL7305910 | 0.87 | KMT2A (0.55) | CKS1BSKP1SKP2GPR119KMT2A | |
| SCHEMBL5351275 | 0.81 | KDM4E (0.62) | KDM4EPKMCKS1BSKP1SKP2 | |
| SCHEMBL25232232 | 0.78 | KDM4E (0.58) | KDM4EPKMCKS1BSKP1SKP2 | |
| SCHEMBL9354845 | 0.77 | SIGMAR1 (0.56) | YAP1KMT2AMEN1MAPK1 | |
| SCHEMBL9354851 | 0.77 | SIGMAR1 (0.56) | YAP1KMT2AMEN1MAPK1 | |
| SCHEMBL1241067 | 0.77 | KDM4E (0.69) | KDM4EPKMYAP1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417698-B1 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AG (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5374731-A | Treatment of high blood pressure, congestive heart failure and viral disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| EP-0417698-A2 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | disclosed |