Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314000 | 0.85 | SMN1; SMN2 (0.44) | ALDH1A1MEN1KMT2ASMN1; SMN2KIF11 | |
| SCHEMBL9475546 | 0.80 | KMT2A (0.50) | ALDH1A1LMNAMEN1KMT2AALOX15 | |
| SCHEMBL8307755 | 0.73 | MAPT (0.44) | ALDH1A1LMNAMEN1KMT2AALOX15 | |
| SCHEMBL11014866 | 0.72 | KMT2A (0.50) | ALDH1A1LMNAKMT2AALOX15APEX1 | |
| SCHEMBL2008587 | 0.72 | NR1H4 (0.53) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL5877820 | 0.71 | ESR1 (0.47) | ALDH1A1LMNAMEN1KMT2AALOX15 | |
| SCHEMBL11562974 | 0.70 | MAPT (0.56) | ALDH1A1LMNAMEN1KMT2AALOX15 | |
| SCHEMBL7372260 | 0.70 | MAPT (0.44) | ALDH1A1LMNAMEN1KMT2AALOX15 | |
| SCHEMBL13757731 | 0.70 | KMT2A (0.50) | ALDH1A1LMNAMEN1KMT2AALOX15 | |
| SCHEMBL28065294 | 0.69 | KMT2A (0.55) | ALDH1A1LMNAMEN1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0911333-B1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6235742-B1 | CARDIOVASCULAR DISORDERS; ANTIALLERGENS | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0911333-A1 | Pyrazolo[4,3-d]pyrimidine derivatives and pharmaceutical compositions containing them | PFIZER INC. (US) | 1999-04-28 | — | — | EP | disclosed |