SCHEMBL7307191

SCHEMBL7307191

CCCC(C)CCCCC([NH])=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACE2 Q9BYF1 1/20 0.46
ALDH1A1 P00352 1/20 0.40
TSHR P16473 1/20 0.39
MAPT P10636 1/20 0.38
FFAR4 Q5NUL3 1/20 0.37
FFAR1 O14842 1/20 0.37
CA1 P00915 2/20 0.36
LMNA P02545 3/20 0.36
BLM P54132 1/20 0.35
CES2 O00748 2/20 0.34
CES1 P23141 2/20 0.34
MEN1 O00255 1/20 0.34
FAAH O00519 1/20 0.34
MAPK1 P28482 1/20 0.34
KMT2A Q03164 1/20 0.34
CHRM1 P11229 1/20 0.33
AKR1A1 P14550 1/20 0.33
CHRM3 P20309 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7307113 0.94 ACE2 (0.42) ACE2ALDH1A1TSHRMAPTCA1
SCHEMBL7740680 0.90 ACE2 (0.53) ACE2ALDH1A1TSHRFFAR4FFAR1
SCHEMBL7312905 0.85 TSHR (0.44) ACE2ALDH1A1TSHRMAPTCA1
SCHEMBL4182137 0.81 ACE2 (0.47) ACE2MAPTCA1BLMCES2
SCHEMBL1781703 0.81 ACE2 (0.47) ACE2ALDH1A1TSHRMAPTFFAR4
SCHEMBL3629224 0.81 ALDH1A1 (0.60) ACE2ALDH1A1TSHRMAPTFFAR4
SCHEMBL8811478 0.81 ACE2 (0.47) ACE2ALDH1A1TSHRMAPTFFAR4
SCHEMBL10480678 0.79 ACE2 (0.50) ACE2ALDH1A1TSHRMAPTFFAR4
SCHEMBL15368117 0.79 ACE2 (0.50) ACE2ALDH1A1TSHRMAPTFFAR4
SCHEMBL5879050 0.79 ALDH1A1 (0.63) ACE2ALDH1A1TSHRMAPTFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5614519-A (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists KARL THOMAE GMBH (DE) 1997-03-25 US disclosed
US-5602127-A ADMINISTERING TO TREAT HYPERTENSION KARL THOMAE GMBH (DE) 1997-02-11 US disclosed
US-5594003-A HYPOTENSIVE AGENTS DR. KARL THOMAE GMBH (DE) 1997-01-14 US disclosed
US-5591762-A HYPOTENSIVE AGENTS DR. KARL THOMAE GMBH (DE) 1997-01-07 US disclosed
EP-0502314-A1 Benzimidazol, medicaments containing them and process for their preparation Dr. Karl Thomae GmbH (DE) 1992-09-09 EP disclosed