Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144108 | 0.86 | HSD17B10 (0.51) | HSD17B10PTGS1AKR1C3AKR1C2POLB | |
| SCHEMBL7322443 | 0.85 | HSD17B10 (0.68) | HSD17B10PTGS1AKR1C3AKR1C2POLB | |
| SCHEMBL30468420 | 0.85 | HSD17B10 (0.68) | HSD17B10PTGS1AKR1C3AKR1C2POLB | |
| SCHEMBL7308036 | 0.85 | HSD17B10 (0.50) | HSD17B10PTGS1AKR1C3AKR1C2POLB | |
| SCHEMBL7314138 | 0.84 | POLB (0.48) | HSD17B10POLBKDM4ENPC1RAB9A | |
| SCHEMBL10962956 | 0.82 | AKR1C3 (0.52) | HSD17B10PTGS1AKR1C3AKR1C2MTNR1A | |
| SCHEMBL16836022 | 0.81 | HSD17B10 (0.50) | HSD17B10PTGS1AKR1C3AKR1C2POLB | |
| SCHEMBL892777 | 0.81 | HSD17B10 (0.73) | HSD17B10MEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL8237110 | 0.81 | HSD17B10 (0.50) | HSD17B10PTGS1AKR1C3AKR1C2POLB | |
| SCHEMBL30660236 | 0.81 | HSD17B10 (0.73) | HSD17B10MEN1KMT2AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742084-A | Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives | MCNEILAB, INC. (US) | 1988-05-03 | — | — | US | disclosed |
| US-4661635-A | ANTIARRHYTHMIA AGENTS | MCNEILAB, INC. (US) | 1987-04-28 | — | — | US | disclosed |
| EP-0146271-A2 | Aralykyl (arylethynyl) aralkyl amines for use as vasodilators and antihypertensives | McNeilab, Inc. (US) | 1985-06-26 | — | — | EP | disclosed |