Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304224 | 0.98 | OPRM1 (0.42) | OPRM1OPRK1OPRD1NPC1HRH3 | |
| SCHEMBL7306774 | 0.95 | OPRM1 (0.39) | OPRM1OPRK1OPRD1HRH3CYSLTR2 | |
| SCHEMBL7337609 | 0.92 | HRH3 (0.39) | OPRM1OPRK1OPRD1NPC1HRH3 | |
| SCHEMBL7302728 | 0.91 | OPRM1 (0.38) | OPRM1OPRK1OPRD1HRH3SLC6A2 | |
| SCHEMBL7296929 | 0.90 | HRH3 (0.40) | OPRM1OPRK1OPRD1NPC1HRH3 | |
| SCHEMBL7302580 | 0.90 | NPC1 (0.39) | OPRM1OPRK1OPRD1NPC1HRH3 | |
| SCHEMBL4620956 | 0.88 | NPC1 (0.36) | OPRM1OPRK1OPRD1NPC1HRH3 | |
| SCHEMBL7327424 | 0.87 | MEN1 (0.38) | OPRM1OPRK1OPRD1HRH3SLC6A2 | |
| SCHEMBL7295826 | 0.84 | NPC1 (0.32) | NPC1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7323836 | 0.84 | NPC1 (0.35) | NPC1HRH3SLC6A2HRH1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |